Product Data Sheet
RL648_81
Catalog No. A68021
RL648_81 is a selective activator of the KQT-like subfamily 2/3 (KCNQ2/3) channels, exhibiting an EC50 of 190 nM. This compound effectively induces a hyperpolarizing shift in V1/2 for KCNQ2/3, while showing no effect on KCNQ4 or KCNQ5 channels. RL648_81 holds promise for research involving neurological disorders linked to neuronal hyperexcitability.
Chemical Information
| Catalog Num | A68021 |
|---|---|
| M. Wt | 371.33 |
| Formula | C17H17F4N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1919050-87-5 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(C(F)=C1N)NCC2=CC=C(C=C2)C(F)(F)F)OCC |
Biological Activity
| Description | RL648_81 is a selective activator of the KQT-like subfamily 2/3 (KCNQ2/3) channels, exhibiting an EC50 of 190 nM. This compound effectively induces a hyperpolarizing shift in V1/2 for KCNQ2/3, while showing no effect on KCNQ4 or KCNQ5 channels. RL648_81 holds promise for research involving neurological disorders linked to neuronal hyperexcitability. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
