Product Data Sheet
VU0810464
Catalog No. A68031
VU0810464 is a potent and selective activator of G protein-gated inwardly rectifying potassium channels (GIRK, Kir3). It demonstrates nanomolar potency for neuronal GIRK channels (EC50=165 nM) and GIRK1/4 channels (EC50=720 nM), facilitating efficient modulation of neuronal excitability. The compound is particularly noteworthy for its enhanced brain penetration, making it a valuable tool for research focused on neuronal signaling and disorders involving GIRK channel dysfunction.
Chemical Information
| Catalog Num | A68031 |
|---|---|
| M. Wt | 349.83 |
| Formula | C18H21ClFN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2126040-21-7 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C)=NN1C2CCCCC2)CC3=CC=C(F)C(Cl)=C3 |
Biological Activity
| Description | VU0810464 is a potent and selective activator of G protein-gated inwardly rectifying potassium channels (GIRK, Kir3). It demonstrates nanomolar potency for neuronal GIRK channels (EC50=165 nM) and GIRK1/4 channels (EC50=720 nM), facilitating efficient modulation of neuronal excitability. The compound is particularly noteworthy for its enhanced brain penetration, making it a valuable tool for research focused on neuronal signaling and disorders involving GIRK channel dysfunction. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
