Product Data Sheet
NS004
Catalog No. A68033
NS004 is a potent activator of large-conductance calcium-activated potassium (BK) channels, enhancing Iberiotoxin and Tetraethylammonium-sensitive whole-cell efflux currents. This compound significantly boosts the activity of individual BK channels in GH3 cells and rat brain channels integrated into planar lipid bilayers. The observed effects include increased channel mean open time, reduced intermittent time, and enhanced voltage and calcium sensitivity, making NS004 valuable for research on potassium channel modulation and related physiological processes.
Chemical Information
| Catalog Num | A68033 |
|---|---|
| M. Wt | 328.67 |
| Formula | C14H8ClF3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 141797-92-4 |
| Synonyms | |
| SMILES | O=C1N(C2=CC=C(C=C2N1)C(F)(F)F)C3=CC(Cl)=CC=C3O |
Biological Activity
| Description | NS004 is a potent activator of large-conductance calcium-activated potassium (BK) channels, enhancing Iberiotoxin and Tetraethylammonium-sensitive whole-cell efflux currents. This compound significantly boosts the activity of individual BK channels in GH3 cells and rat brain channels integrated into planar lipid bilayers. The observed effects include increased channel mean open time, reduced intermittent time, and enhanced voltage and calcium sensitivity, making NS004 valuable for research on potassium channel modulation and related physiological processes. |
|---|
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
