Product Data Sheet
A1899
Catalog No. A68047
A1899 is a selective blocker of the two-pore potassium channel TASK-1, exhibiting IC50 values of 35.1 nM in oocytes and 7 nM in CHO cells. Additionally, A1899 functions as an IKur blocker, making it a valuable tool in the study of cardiac electrophysiology and related cardiovascular diseases. Its potency and specificity allow for detailed investigation into the physiological roles of potassium channels in cellular and cardiovascular research.
Chemical Information
| Catalog Num | A68047 |
|---|---|
| M. Wt | 500.54 |
| Formula | C30H26F2N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 498577-46-1 |
| Synonyms | S20951 |
| SMILES | O=C(NCC1=CC=C(C=C1F)F)C2=CC=CC=C2C3=CC=CC=C3CNC(CC4=CC=C(C=C4)OC)=O |
Biological Activity
| Description | A1899 is a selective blocker of the two-pore potassium channel TASK-1, exhibiting IC50 values of 35.1 nM in oocytes and 7 nM in CHO cells. Additionally, A1899 functions as an IKur blocker, making it a valuable tool in the study of cardiac electrophysiology and related cardiovascular diseases. Its potency and specificity allow for detailed investigation into the physiological roles of potassium channels in cellular and cardiovascular research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
