Product Data Sheet
PF-05020182
Catalog No. A68129
PF-05020182 is an orally active Kv7 channel activator that specifically targets human Kv7.2/7.3, Kv7.4, and Kv7.3/7.5 channels, with EC50 values of 334, 625, and 588 nM, respectively. This compound demonstrates significant anticonvulsant activity in rat models of corneal electric shock-induced tonic seizures. Additionally, PF-05020182 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research applications.
Chemical Information
| Catalog Num | A68129 |
|---|---|
| M. Wt | 366.46 |
| Formula | C18H30N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1354712-92-7 |
| Synonyms | |
| SMILES | O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC |
Biological Activity
| Description | PF-05020182 is an orally active Kv7 channel activator that specifically targets human Kv7.2/7.3, Kv7.4, and Kv7.3/7.5 channels, with EC50 values of 334, 625, and 588 nM, respectively. This compound demonstrates significant anticonvulsant activity in rat models of corneal electric shock-induced tonic seizures. Additionally, PF-05020182 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
