Product Data Sheet
Kv7.2/Kv7.3 agonist 1
Catalog No. A68138
Kv7.2/Kv7.3 agonist 1 is a potent orally active agonist targeting the KV7.2/7.3 channels (KCNQ2/3), exhibiting an EC50 value of 1.03 μM. This compound demonstrates significant analgesic effects in both the chronic constriction injury (CCI) model and the Streptozotocin-induced diabetic peripheral neuropathic pain (DPNP) model, with effective doses (ED50) of 12.02 mg/kg and 9.63 mg/kg, respectively. It serves as a valuable tool for research into pain management and neurological conditions associated with Kv7 channel modulation.
Chemical Information
| Catalog Num | A68138 |
|---|---|
| M. Wt | 275.28 |
| Formula | C14H14FN3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2315450-35-0 |
| Synonyms | |
| SMILES | CC(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)=O |
Biological Activity
| Description | Kv7.2/Kv7.3 agonist 1 is a potent orally active agonist targeting the KV7.2/7.3 channels (KCNQ2/3), exhibiting an EC50 value of 1.03 μM. This compound demonstrates significant analgesic effects in both the chronic constriction injury (CCI) model and the Streptozotocin-induced diabetic peripheral neuropathic pain (DPNP) model, with effective doses (ED50) of 12.02 mg/kg and 9.63 mg/kg, respectively. It serves as a valuable tool for research into pain management and neurological conditions associated with Kv7 channel modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
