Product Data Sheet
BMS-223131
Catalog No. A68148
BMS-223131 is a potent maxi-K potassium channel opener, primarily targeting potassium channels to enhance K+ efflux and hyperpolarize cell membranes, leading to reduced Ca2+ influx. It demonstrates strong inhibitory activity on the CYP2C9 enzyme (IC50 = 1.7 μM) and modulates several other CYP enzymes, including CYP1A2, CYP2C19, CYP2D6, and CYP3A4. This compound is valuable in research focused on neurological diseases, particularly stroke, due to its ability to influence ion channel activity and cellular excitability.
Chemical Information
| Catalog Num | A68148 |
|---|---|
| M. Wt | 383.75 |
| Formula | C18H13ClF3NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 275375-69-4 |
| Synonyms | |
| SMILES | O=C1NC2=C(C=C(C(F)(F)F)C=C2)C(C3=CC(Cl)=CC=C3O)=C1CCO |
Biological Activity
| Description | BMS-223131 is a potent maxi-K potassium channel opener, primarily targeting potassium channels to enhance K+ efflux and hyperpolarize cell membranes, leading to reduced Ca2+ influx. It demonstrates strong inhibitory activity on the CYP2C9 enzyme (IC50 = 1.7 μM) and modulates several other CYP enzymes, including CYP1A2, CYP2C19, CYP2D6, and CYP3A4. This compound is valuable in research focused on neurological diseases, particularly stroke, due to its ability to influence ion channel activity and cellular excitability. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
