Product Data Sheet
Aprikalim
Catalog No. A68153
Aprikalim is a potassium channel activator that primarily targets ATP-sensitive K+ (KATP) channels. It has been shown to enhance KATP channel activity in guinea pig ventricular myocytes, particularly in Mg-NDP solutions, where it reduces ATP sensitivity and increases the K1 value from 56 μM to 180 μM. This property highlights the potential of Aprikalim in modulating cardiac excitability and suggests its relevance in exploring therapeutic strategies for cardiac conditions. Its effects on KATP channel functionality may also provide insights into the enzymatic activity of channel proteins under various experimental conditions.
Chemical Information
| Catalog Num | A68153 |
|---|---|
| M. Wt | 268.40 |
| Formula | C12H16N2OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 132562-26-6 |
| Synonyms | RP 52891 |
| SMILES | S=C([C@]1(C2=CC=CN=C2)CCCC[S@]1=O)NC |
Biological Activity
| Description | Aprikalim is a potassium channel activator that primarily targets ATP-sensitive K+ (KATP) channels. It has been shown to enhance KATP channel activity in guinea pig ventricular myocytes, particularly in Mg-NDP solutions, where it reduces ATP sensitivity and increases the K1 value from 56 μM to 180 μM. This property highlights the potential of Aprikalim in modulating cardiac excitability and suggests its relevance in exploring therapeutic strategies for cardiac conditions. Its effects on KATP channel functionality may also provide insights into the enzymatic activity of channel proteins under various experimental conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
