Product Data Sheet
BA6b9
Catalog No. A68279
BA6b9 is an allosteric inhibitor of SK4 channels, specifically targeting the CaM–PIP2-binding domain with an IC50 value of 8.6 µM for wild-type SK4. This compound inhibits SK4 channel activity by interacting with two critical residues, Arg191 and His192, in the S4–S5 linker. In preclinical studies using isolated rat hearts, BA6b9 significantly prolongs both atrial and atrioventricular effective refractory periods (ERP) while reducing the induction of atrial fibrillation (AF), showcasing its potential application in arrhythmia research.
Chemical Information
| Catalog Num | A68279 |
|---|---|
| M. Wt | 233.31 |
| Formula | C14H19NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 609335-29-7 |
| Synonyms | |
| SMILES | O=C1OC2=C(N1CCCCCCC)C=CC=C2 |
Biological Activity
| Description | BA6b9 is an allosteric inhibitor of SK4 channels, specifically targeting the CaM–PIP2-binding domain with an IC50 value of 8.6 µM for wild-type SK4. This compound inhibits SK4 channel activity by interacting with two critical residues, Arg191 and His192, in the S4–S5 linker. In preclinical studies using isolated rat hearts, BA6b9 significantly prolongs both atrial and atrioventricular effective refractory periods (ERP) while reducing the induction of atrial fibrillation (AF), showcasing its potential application in arrhythmia research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
