Product Data Sheet
Vonoprazan Fumarate
Catalog No. A68327
Vonoprazan Fumarate is a potent potassium-competitive acid blocker (P-CAB) that exerts its effect by inhibiting H+,K+-ATPase activity, demonstrating an IC50 of 19 nM at pH 6.5 in porcine gastric microsomes. This compound exhibits significant antisecretory activity, making it valuable for investigating acid-related disorders. Research applications include studies related to gastroesophageal reflux disease and peptic ulcer disease, where it may provide insights into therapeutic mechanisms.
Chemical Information
| Catalog Num | A68327 |
|---|---|
| M. Wt | 461.46 |
| Formula | C21H20FN3O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 881681-01-2 |
| Synonyms | TAK-438 |
| SMILES | O=C(O)/C=C/C(O)=O.O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O |
Biological Activity
| Description | Vonoprazan Fumarate is a potent potassium-competitive acid blocker (P-CAB) that exerts its effect by inhibiting H+,K+-ATPase activity, demonstrating an IC50 of 19 nM at pH 6.5 in porcine gastric microsomes. This compound exhibits significant antisecretory activity, making it valuable for investigating acid-related disorders. Research applications include studies related to gastroesophageal reflux disease and peptic ulcer disease, where it may provide insights into therapeutic mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
