Product Data Sheet
FR-167356
Catalog No. A68366
FR-167356 is a selective inhibitor of vacuolar ATPase, exhibiting potent activity with IC50 values of 170 nM for osteoclast plasma membranes, 220 nM for macrophage microsomes, and higher values for renal brush border and liver lysosomal membranes. This compound inhibits bone resorption and effectively addresses ovariectomy-induced bone loss. It serves as a valuable tool for research into osteoporosis and related bone disorders.
Chemical Information
| Catalog Num | A68366 |
|---|---|
| M. Wt | 378.25 |
| Formula | C19H17Cl2NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 174185-16-1 |
| Synonyms | |
| SMILES | O=C(NC1=C(OC(C)=C2C(C)(O)C)C2=CC=C1)C3=C(Cl)C=CC=C3Cl |
Biological Activity
| Description | FR-167356 is a selective inhibitor of vacuolar ATPase, exhibiting potent activity with IC50 values of 170 nM for osteoclast plasma membranes, 220 nM for macrophage microsomes, and higher values for renal brush border and liver lysosomal membranes. This compound inhibits bone resorption and effectively addresses ovariectomy-induced bone loss. It serves as a valuable tool for research into osteoporosis and related bone disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
