Product Data Sheet
Remogliflozin etabonate
Catalog No. A68391
Remogliflozin etabonate is a selective inhibitor of the sodium glucose cotransporter 2 (SGLT2), exhibiting Ki values of 1.95 μM for human SGLT2, 2.14 μM for rat SGLT2, 43.1 μM for human SGLT1, and 8.57 μM for rat SGLT1. As a prodrug derived from benzylpyrazole glucoside, it is metabolized into its active form, Remogliflozin, in vivo. This compound demonstrates significant antidiabetic activity in rodent models, making it a valuable tool for research into glucose regulation and diabetes therapies.
Chemical Information
| Catalog Num | A68391 |
|---|---|
| M. Wt | 522.59 |
| Formula | C26H38N2O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 442201-24-3 |
| Synonyms | GSK189075 |
| SMILES | CCOC(OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC2=NN(C(C)C)C(C)=C2CC3=CC=C(OC(C)C)C=C3)=O |
Biological Activity
| Description | Remogliflozin etabonate is a selective inhibitor of the sodium glucose cotransporter 2 (SGLT2), exhibiting Ki values of 1.95 μM for human SGLT2, 2.14 μM for rat SGLT2, 43.1 μM for human SGLT1, and 8.57 μM for rat SGLT1. As a prodrug derived from benzylpyrazole glucoside, it is metabolized into its active form, Remogliflozin, in vivo. This compound demonstrates significant antidiabetic activity in rodent models, making it a valuable tool for research into glucose regulation and diabetes therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
