Product Data Sheet
Mizagliflozin (sebacate)
Catalog No. A68407
Mizagliflozin (sebacate) is a selective inhibitor of sodium-glucose cotransporter 1 (SGLT1), demonstrating significant potential in enhancing vascular cognitive impairment associated with small vessel disease. By inhibiting SGLT1 activity in neurons, Mizagliflozin (sebacate) effectively improves cerebral blood flow and cognitive functions such as spatial learning and memory in relevant mouse models. Additionally, Mizagliflozin (sebacate) has been shown to increase the survival rate of IL-1β-treated PC12HS cells, supporting its role in neuroprotection. This compound is valuable for research into therapeutic strategies for cognitive deficits linked to vascular health.
Chemical Information
| Catalog Num | A68407 |
|---|---|
| M. Wt | 1331.59 |
| Formula | C28H44N4O8.1/2C10H18O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1169392-27-1 |
| Synonyms | DSP-3235 (sebacate); KGA-3235 (sebacate); GSK-1614235 (sebacate) |
| SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=NNC(C(C)C)=C2CC3=C(C=C(C=C3)OCCCNCC(C)(C)C(N)=O)C.OC(CCCCCCCCC(O)=O)=O.[0.5] |
Biological Activity
| Description | Mizagliflozin (sebacate) is a selective inhibitor of sodium-glucose cotransporter 1 (SGLT1), demonstrating significant potential in enhancing vascular cognitive impairment associated with small vessel disease. By inhibiting SGLT1 activity in neurons, Mizagliflozin (sebacate) effectively improves cerebral blood flow and cognitive functions such as spatial learning and memory in relevant mouse models. Additionally, Mizagliflozin (sebacate) has been shown to increase the survival rate of IL-1β-treated PC12HS cells, supporting its role in neuroprotection. This compound is valuable for research into therapeutic strategies for cognitive deficits linked to vascular health. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
