Product Data Sheet
PF-06456384 trihydrochloride
Catalog No. A68427
PF-06456384 trihydrochloride is a highly potent and selective blocker of the NaV1.7 sodium channel, exhibiting an IC50 value of 0.01 nM for human NaV1.7, 75 nM for rat NaV1.7, and less than 0.1 nM for mouse NaV1.7. This compound is instrumental in researching pain pathways and the physiological role of NaV1.7 in nociception. Notably, PF-06456384 trihydrochloride has shown minimal analgesic efficacy in animal models such as the mouse Formalin pain model, highlighting its specificity in sodium channel modulation.
Chemical Information
| Catalog Num | A68427 |
|---|---|
| M. Wt | 829.18 |
| Formula | C35H35Cl3F3N7O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1834610-75-1 |
| Synonyms | |
| SMILES | N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.[H]Cl.[H]Cl.[H]Cl |
Biological Activity
| Description | PF-06456384 trihydrochloride is a highly potent and selective blocker of the NaV1.7 sodium channel, exhibiting an IC50 value of 0.01 nM for human NaV1.7, 75 nM for rat NaV1.7, and less than 0.1 nM for mouse NaV1.7. This compound is instrumental in researching pain pathways and the physiological role of NaV1.7 in nociception. Notably, PF-06456384 trihydrochloride has shown minimal analgesic efficacy in animal models such as the mouse Formalin pain model, highlighting its specificity in sodium channel modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
