Product Data Sheet
VGSC blocker-1
Catalog No. A68578
VGSC blocker-1 is a selective blocker of the neonatal voltage-gated sodium channel subtype Nav1.5 (nNav1.5). This small molecule inhibits peak sodium currents by 34.9% at a concentration of 1 μM, and it demonstrates a significant reduction in cell invasion by 0.3% at the same concentration in the MDA-MB-231 human breast cancer cell line, all while maintaining cell viability. VGSC blocker-1 is valuable for research into mechanisms of cancer metastasis and ion channel function in cellular processes.
Chemical Information
| Catalog Num | A68578 |
|---|---|
| M. Wt | 386.52 |
| Formula | C24H32F2N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2230472-55-4 |
| Synonyms | |
| SMILES | FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCCCN3CCCCC3)C=C1 |
Biological Activity
| Description | VGSC blocker-1 is a selective blocker of the neonatal voltage-gated sodium channel subtype Nav1.5 (nNav1.5). This small molecule inhibits peak sodium currents by 34.9% at a concentration of 1 μM, and it demonstrates a significant reduction in cell invasion by 0.3% at the same concentration in the MDA-MB-231 human breast cancer cell line, all while maintaining cell viability. VGSC blocker-1 is valuable for research into mechanisms of cancer metastasis and ion channel function in cellular processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
