Product Data Sheet
Nav1.7-IN-8
Catalog No. A68619
Nav1.7-IN-8 is a selective inhibitor of NaV1.7, demonstrating a high degree of specificity for this subtype compared to hNaV1.1 and hNaV1.5. It effectively inhibits CYP2C9 and CYP3A4 enzymes with IC50 values of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 exhibits significant analgesic properties, making it a valuable tool for research in pain management and studies related to acute and inflammatory pain pathways.
Chemical Information
| Catalog Num | A68619 |
|---|---|
| M. Wt | 535.93 |
| Formula | C21H12ClF2N5O4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1432913-44-4 |
| Synonyms | |
| SMILES | O=S(NC1=NC=NS1)(C2=C(F)C=C(OC3=C(C4=CC=C5ON=C(C5=C4)N)C=C(Cl)C=C3)C(F)=C2)=O |
Biological Activity
| Description | Nav1.7-IN-8 is a selective inhibitor of NaV1.7, demonstrating a high degree of specificity for this subtype compared to hNaV1.1 and hNaV1.5. It effectively inhibits CYP2C9 and CYP3A4 enzymes with IC50 values of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 exhibits significant analgesic properties, making it a valuable tool for research in pain management and studies related to acute and inflammatory pain pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
