Product Data Sheet
PF-05150122
Catalog No. A68620
PF-05150122 is a potent and selective inhibitor of the human Nav1.7 sodium channel, which plays a critical role in pain signaling pathways. This compound effectively modulates pain responses, making it a valuable tool for research into mechanisms of acute and chronic pain. Favorable biopharmacokinetic properties have been observed in microdose studies, supporting its potential for further exploration in pain management applications. The predicted pharmacokinetic profile suggests significant efficacy in reducing the inhibitory concentration (IC50) of Nav1.7, highlighting its promise for therapeutic development.
Chemical Information
| Catalog Num | A68620 |
|---|---|
| M. Wt | 541.04 |
| Formula | C24H21ClN6O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1235406-00-4 |
| Synonyms | |
| SMILES | N#CC1=CC(S(=O)(NC2=CSC=N2)=O)=CC=C1OC3=C(C4=CC=NN4C5CN(C5)CC)C=C(Cl)C=C3 |
Biological Activity
| Description | PF-05150122 is a potent and selective inhibitor of the human Nav1.7 sodium channel, which plays a critical role in pain signaling pathways. This compound effectively modulates pain responses, making it a valuable tool for research into mechanisms of acute and chronic pain. Favorable biopharmacokinetic properties have been observed in microdose studies, supporting its potential for further exploration in pain management applications. The predicted pharmacokinetic profile suggests significant efficacy in reducing the inhibitory concentration (IC50) of Nav1.7, highlighting its promise for therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
