Product Data Sheet

Nav1.8-IN-14

Catalog No. A68631

main product photo
Nav1.8-IN-14 is a selective inhibitor of the voltage-gated sodium channel Nav1.8, known for its role in the transmission of pain signals. This compound demonstrates potent activity in modulating Nav1.8 function and has significant implications for the study of pain-related diseases, including neuropathic pain and inflammatory conditions. Research applications include investigations into the mechanistic pathways of pain sensation and the development of novel analgesic therapies.
Chemical Information
Catalog NumA68631
M. Wt464.41
FormulaC18H17F5N4O3S
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.2417373-18-1
Synonyms
SMILESFC(F)(F)C1=CN=C(N(CC2)CCC2(F)F)C(C(NC3=CC(S(N)(=O)=O)=CC=C3)=O)=C1
Biological Activity
DescriptionNav1.8-IN-14 is a selective inhibitor of the voltage-gated sodium channel Nav1.8, known for its role in the transmission of pain signals. This compound demonstrates potent activity in modulating Nav1.8 function and has significant implications for the study of pain-related diseases, including neuropathic pain and inflammatory conditions. Research applications include investigations into the mechanistic pathways of pain sensation and the development of novel analgesic therapies.
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