Product Data Sheet
PF-05214030
Catalog No. A68730
PF-05214030 is a potent TRPV4 antagonist, exhibiting IC50 values of 4 nM for human TRPV4 and 27 nM for rat TRPV4. This compound effectively counteracts the decrease in bladder capacity induced by intravesical administration of a TRPV4 agonist. PF-05214030 is therefore a valuable tool for investigating the role of TRPV4 in bladder physiology and may hold potential for therapeutic applications in bladder dysfunction research.
Chemical Information
| Catalog Num | A68730 |
|---|---|
| M. Wt | 431.27 |
| Formula | C17H13Cl2FN2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1669444-50-1 |
| Synonyms | |
| SMILES | N#CC1=CC=C(C=C1F)OCC2(CN(S(=O)(C3=CC=C(C=C3Cl)Cl)=O)C2)O |
Biological Activity
| Description | PF-05214030 is a potent TRPV4 antagonist, exhibiting IC50 values of 4 nM for human TRPV4 and 27 nM for rat TRPV4. This compound effectively counteracts the decrease in bladder capacity induced by intravesical administration of a TRPV4 agonist. PF-05214030 is therefore a valuable tool for investigating the role of TRPV4 in bladder physiology and may hold potential for therapeutic applications in bladder dysfunction research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
