Product Data Sheet
TRPC6-PAM-C20
Catalog No. A68738
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) targeting TRPC6 channels. This compound significantly enhances channel activation at low basal concentrations of diacylglycerol (DAG), facilitating increases in intracellular calcium ([Ca2+]i) levels in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 serves as an essential reagent for researchers investigating TRPC6-dependent signaling pathways and calcium dynamics.
Chemical Information
| Catalog Num | A68738 |
|---|---|
| M. Wt | 363.41 |
| Formula | C22H21NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 667427-75-0 |
| Synonyms | |
| SMILES | O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1 |
Biological Activity
| Description | TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) targeting TRPC6 channels. This compound significantly enhances channel activation at low basal concentrations of diacylglycerol (DAG), facilitating increases in intracellular calcium ([Ca2+]i) levels in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 serves as an essential reagent for researchers investigating TRPC6-dependent signaling pathways and calcium dynamics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
