Product Data Sheet
AMG 9090
Catalog No. A68805
AMG 9090 is a partial agonist of the rat TRPA1 channel, exhibiting significant pharmacological activity in models of pain and inflammation. TRPA1 plays a critical role in detecting reactive compounds that induce pain responses in both humans and rodents. Notably, AMG 9090 demonstrates a distinct antagonistic effect on human TRPA1 activated by AITC and noxious cold, while functioning as a partial agonist in rat TRPA1. This profile highlights the compound’s potential utility as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory effects observed on TRPM8 channels.
Chemical Information
| Catalog Num | A68805 |
|---|---|
| M. Wt | 395.13 |
| Formula | C15H11Cl4NOS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 118215-82-0 |
| Synonyms | |
| SMILES | ClC(Cl)(Cl)C(SC1=CC=C(Cl)C=C1)NC(C2=CC=CC=C2)=O |
Biological Activity
| Description | AMG 9090 is a partial agonist of the rat TRPA1 channel, exhibiting significant pharmacological activity in models of pain and inflammation. TRPA1 plays a critical role in detecting reactive compounds that induce pain responses in both humans and rodents. Notably, AMG 9090 demonstrates a distinct antagonistic effect on human TRPA1 activated by AITC and noxious cold, while functioning as a partial agonist in rat TRPA1. This profile highlights the compound’s potential utility as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory effects observed on TRPM8 channels. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
