Product Data Sheet
KJM429
Catalog No. A68827
KJM429 is a high-affinity ligand targeting the rat vanilloid receptor rTRPV1, exhibiting a Ki value of 30-63 nM. This compound functions as a competitive antagonist to inhibit TRPV1 activation by stimuli such as capsaicin, resiniferatoxin, and thermal signals, while switching to an agonist role under acidic conditions (pH < 5.5). KJM429 effectively modulates calcium influx associated with TRPV1 activation, making it a valuable tool for investigating the mechanisms underlying pain-related disorders, including postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis, and pruritus.
Chemical Information
| Catalog Num | A68827 |
|---|---|
| M. Wt | 405.58 |
| Formula | C20H27N3O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 401907-57-1 |
| Synonyms | MK-056 |
| SMILES | O=S(=O)(NC1=CC=C(C=C1)CNC(=S)NCC2=CC=C(C=C2)C(C)(C)C)C |
Biological Activity
| Description | KJM429 is a high-affinity ligand targeting the rat vanilloid receptor rTRPV1, exhibiting a Ki value of 30-63 nM. This compound functions as a competitive antagonist to inhibit TRPV1 activation by stimuli such as capsaicin, resiniferatoxin, and thermal signals, while switching to an agonist role under acidic conditions (pH < 5.5). KJM429 effectively modulates calcium influx associated with TRPV1 activation, making it a valuable tool for investigating the mechanisms underlying pain-related disorders, including postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis, and pruritus. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
