Product Data Sheet
AMG8788
Catalog No. A68841
AMG8788 is a selective, orally active antagonist of the transient receptor potential melastatin 8 (TRPM8), exhibiting an IC50 of 63.2 nM. This compound demonstrates significant inhibitory activity on TRPM8, making it valuable for studying sensory perception, pain pathways, and thermoregulation. It serves as an important tool for research into conditions associated with TRPM8 modulation, including neuropathic pain and cold sensitivity.
Chemical Information
| Catalog Num | A68841 |
|---|---|
| M. Wt | 414.40 |
| Formula | C23H18F4N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1159996-43-6 |
| Synonyms | |
| SMILES | O=C(N1CCC2=C(C=CC=C2)[C@H]1C3=CC=C(C(F)(F)F)C=C3)NC4=CC=C(F)C=C4 |
Biological Activity
| Description | AMG8788 is a selective, orally active antagonist of the transient receptor potential melastatin 8 (TRPM8), exhibiting an IC50 of 63.2 nM. This compound demonstrates significant inhibitory activity on TRPM8, making it valuable for studying sensory perception, pain pathways, and thermoregulation. It serves as an important tool for research into conditions associated with TRPM8 modulation, including neuropathic pain and cold sensitivity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
