Product Data Sheet
TRPV1 antagonist 9
Catalog No. A68865
TRPV1 antagonist 9 is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits calcium influx in Chinese hamster ovary (CHO) cells expressing TRPV1 receptors, with IC50 values of 0.6 nM for capsaicin and 0.8 nM for acid-induced calcium uptake. This compound has demonstrated the ability to block capsaicin-induced flinch responses and can induce hyperthermia in rat models, making it a valuable tool for exploring nociceptive pathways and pain mechanisms.
Chemical Information
| Catalog Num | A68865 |
|---|---|
| M. Wt | 472.42 |
| Formula | C22H19F3N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 939040-79-6 |
| Synonyms | |
| SMILES | NC1=NC(C(NC1=O)=CC=C2)=C2OC3=NC(NCCOC)=NC(C4=CC=C(C(F)(F)F)C=C4)=C3 |
Biological Activity
| Description | TRPV1 antagonist 9 is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits calcium influx in Chinese hamster ovary (CHO) cells expressing TRPV1 receptors, with IC50 values of 0.6 nM for capsaicin and 0.8 nM for acid-induced calcium uptake. This compound has demonstrated the ability to block capsaicin-induced flinch responses and can induce hyperthermia in rat models, making it a valuable tool for exploring nociceptive pathways and pain mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
