Product Data Sheet
8-Br-7-CH-ADPR
Catalog No. A68873
8-Br-7-CH-ADPR, a specific TRPM2 antagonist, effectively inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel. This modulation controls cation influx through the cell membrane, making it a valuable tool for investigating the physiological and pathological roles of TRPM2. Applications include studying cell death, neurodegenerative diseases, myocardial infarction, and diabetes, providing insights into TRPM2's involvement in various biological processes.
Chemical Information
| Catalog Num | A68873 |
|---|---|
| M. Wt | 637.22 |
| Formula | C16H23BrN4O14P2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1011457-95-6 |
| Synonyms | 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose |
| SMILES | O[C@H]1[C@@H](O)[C@H](N(C(Br)=C2)C3=C2C(N)=NC=N3)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)C(O)O4)(O)=O)(O)=O |
Biological Activity
| Description | 8-Br-7-CH-ADPR, a specific TRPM2 antagonist, effectively inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel. This modulation controls cation influx through the cell membrane, making it a valuable tool for investigating the physiological and pathological roles of TRPM2. Applications include studying cell death, neurodegenerative diseases, myocardial infarction, and diabetes, providing insights into TRPM2's involvement in various biological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
