Product Data Sheet
UT-B-IN-1
Catalog No. A68913
UT-B-IN-1 is a reversible, competitive inhibitor targeting the urea transporter-B (UT-B) with IC50 values of 10 nM for human and 25 nM for mouse UT-B. It demonstrates low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 significantly increases urine output and reduces urine osmolality in murine models, making it a valuable tool for research into diuretic mechanisms and kidney function studies.
Chemical Information
| Catalog Num | A68913 |
|---|---|
| M. Wt | 455.58 |
| Formula | C20H17N5O2S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 892742-76-6 |
| Synonyms | |
| SMILES | O=S(C1=C2N=C(NCC3=CC=CS3)C4=C(C=CS4)N2N=N1)(C5=CC=C(CC)C=C5)=O |
Biological Activity
| Description | UT-B-IN-1 is a reversible, competitive inhibitor targeting the urea transporter-B (UT-B) with IC50 values of 10 nM for human and 25 nM for mouse UT-B. It demonstrates low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 significantly increases urine output and reduces urine osmolality in murine models, making it a valuable tool for research into diuretic mechanisms and kidney function studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
