Product Data Sheet
SKI2852
Catalog No. A68934
SKI2852 is a selective, orally active inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), exhibiting IC50 values of 1.6 nM for mouse HSD1 and 2.9 nM for human HSD1. This compound plays a critical role in the modulation of local glucocorticoid metabolism, making it valuable for research focused on metabolic diseases, obesity, and related disorders. Its potent inhibitory activity positions SKI2852 as a significant tool for investigating the physiological and therapeutic implications of 11β-HSD1 modulation.
Chemical Information
| Catalog Num | A68934 |
|---|---|
| M. Wt | 543.65 |
| Formula | C27H34FN5O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1346554-47-9 |
| Synonyms | |
| SMILES | O=C(C1=NC(N2[C@H](C)CN(C3=CC=C(S(=O)(C)=O)C=C3F)CC2)=NC=C1)N[C@@H]4[C@]5([H])C[C@@]6([H])C[C@](C5)(O)C[C@]4([H])C6 |
Biological Activity
| Description | SKI2852 is a selective, orally active inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), exhibiting IC50 values of 1.6 nM for mouse HSD1 and 2.9 nM for human HSD1. This compound plays a critical role in the modulation of local glucocorticoid metabolism, making it valuable for research focused on metabolic diseases, obesity, and related disorders. Its potent inhibitory activity positions SKI2852 as a significant tool for investigating the physiological and therapeutic implications of 11β-HSD1 modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
