Product Data Sheet
ABT-384
Catalog No. A68938
ABT-384 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with exceptional potency, exhibiting high affinity with Ki values ranging from 0.1 to 2.7 nM across rodent, monkey, and human enzyme targets. By preventing the regeneration of active cortisol, ABT-384 serves as a valuable tool in research investigating the pathophysiology of Alzheimer's disease (AD) and related conditions. Its specific action on cortisol metabolism makes it suitable for studies aimed at understanding the role of glucocorticoids in neurodegenerative disorders.
Chemical Information
| Catalog Num | A68938 |
|---|---|
| M. Wt | 493.56 |
| Formula | C25H34F3N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 868623-40-9 |
| Synonyms | |
| SMILES | NC([C@]12C[C@@H](C3)C(NC(C(C)(N4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)C)=O)[C@@H](C[C@@H]3C2)C1)=O |
Biological Activity
| Description | ABT-384 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with exceptional potency, exhibiting high affinity with Ki values ranging from 0.1 to 2.7 nM across rodent, monkey, and human enzyme targets. By preventing the regeneration of active cortisol, ABT-384 serves as a valuable tool in research investigating the pathophysiology of Alzheimer's disease (AD) and related conditions. Its specific action on cortisol metabolism makes it suitable for studies aimed at understanding the role of glucocorticoids in neurodegenerative disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
