Product Data Sheet
HSD-016
Catalog No. A68940
HSD-016 is a selective and orally bioavailable inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 values of 11 nM, 1 nM, and 8 nM against human, mouse, and rat enzymes, respectively. This reagent plays a significant role in studies related to type 2 diabetes by modulating the conversion of inactive cortisone to active cortisol, thereby influencing glucose metabolism and insulin sensitivity. HSD-016 is valuable for investigating the therapeutic potential of 11β-HSD1 inhibition in metabolic disorders.
Chemical Information
| Catalog Num | A68940 |
|---|---|
| M. Wt | 514.46 |
| Formula | C21H21F7N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 946396-92-5 |
| Synonyms | |
| SMILES | FC(C1=C(C=CC(F)=C1)N2C[C@@H](C)N(CC2)S(=O)(C3=CC([C@@](O)(C(F)(F)F)C)=CC=C3)=O)(F)F |
Biological Activity
| Description | HSD-016 is a selective and orally bioavailable inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 values of 11 nM, 1 nM, and 8 nM against human, mouse, and rat enzymes, respectively. This reagent plays a significant role in studies related to type 2 diabetes by modulating the conversion of inactive cortisone to active cortisol, thereby influencing glucose metabolism and insulin sensitivity. HSD-016 is valuable for investigating the therapeutic potential of 11β-HSD1 inhibition in metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
