Product Data Sheet
HSD17B13-IN-3
Catalog No. A68992
HSD17B13-IN-3 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values of 0.38 μM and 0.45 μM in biochemical assays using β-estradiol and Leukotriene B4 (LTB4) as substrates, respectively, in the presence of NAD+ as a cofactor. This compound is useful for studying the role of HSD17B13 in steroid metabolism and has potential applications in research related to metabolic disorders and inflammatory conditions. However, it exhibits low cell penetration, which may limit its use in certain cellular assays.
Chemical Information
| Catalog Num | A68992 |
|---|---|
| M. Wt | 459.54 |
| Formula | C22H21NO6S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 313259-88-0 |
| Synonyms | |
| SMILES | CC1=C(S(C2=CC=C(C)C=C2)(=O)=O)C=C(C)C=C1S(=O)(NC3=CC=C(C(O)=O)C=C3)=O |
Biological Activity
| Description | HSD17B13-IN-3 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values of 0.38 μM and 0.45 μM in biochemical assays using β-estradiol and Leukotriene B4 (LTB4) as substrates, respectively, in the presence of NAD+ as a cofactor. This compound is useful for studying the role of HSD17B13 in steroid metabolism and has potential applications in research related to metabolic disorders and inflammatory conditions. However, it exhibits low cell penetration, which may limit its use in certain cellular assays. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
