Product Data Sheet

HSD17B13-IN-13

Catalog No. A69025

main product photo
HSD17B13-IN-13 is a selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM for estradiol. This compound is valuable for investigating the role of HSD17B13 in liver pathologies, including non-alcoholic fatty liver disease (NAFLD). Its potent inhibitory activity makes it a useful tool for elucidating the biochemical mechanisms underlying liver disorders and developing therapeutic strategies.
Chemical Information
Catalog NumA69025
M. Wt443.42
FormulaC18H12F3NO5S2
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.2762668-28-8
Synonyms
SMILESCS(=O)(C1=CC=CC(CN2C(S/C(C2=O)=C\C3=C(C(O)=C(C=C3F)F)F)=O)=C1)=O
Biological Activity
DescriptionHSD17B13-IN-13 is a selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM for estradiol. This compound is valuable for investigating the role of HSD17B13 in liver pathologies, including non-alcoholic fatty liver disease (NAFLD). Its potent inhibitory activity makes it a useful tool for elucidating the biochemical mechanisms underlying liver disorders and developing therapeutic strategies.
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