Product Data Sheet
DM243
Catalog No. A69231
DM243 is an EPAC1 activator and STAT3 modulator known for its ability to increase GTP-bound Rap1 levels specifically in EPAC1-expressing cells, while exhibiting no effects on EPAC2 or PKA. This compound effectively reduces IL-6/IL-6Rα-induced STAT3 phosphorylation in endothelial cells and suppresses TGF-β1-mediated fibroblast-to-myofibroblast transition, leading to decreased levels of α-smooth muscle actin and Collagen I in lung fibroblasts. Additionally, DM243 demonstrates minimal cytotoxicity in normal human lung fibroblasts, making it a valuable tool for studies related to fibrosis and inflammation.
Chemical Information
| Catalog Num | A69231 |
|---|---|
| M. Wt | 395.41 |
| Formula | C22H21NO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3106606-59-8 |
| Synonyms | |
| SMILES | O=C(O)C(NCC1=CC=C(OC(C(C2=CC=CC=C2OC)=O)=C3C(C)C)C3=C1)=O |
Biological Activity
| Description | DM243 is an EPAC1 activator and STAT3 modulator known for its ability to increase GTP-bound Rap1 levels specifically in EPAC1-expressing cells, while exhibiting no effects on EPAC2 or PKA. This compound effectively reduces IL-6/IL-6Rα-induced STAT3 phosphorylation in endothelial cells and suppresses TGF-β1-mediated fibroblast-to-myofibroblast transition, leading to decreased levels of α-smooth muscle actin and Collagen I in lung fibroblasts. Additionally, DM243 demonstrates minimal cytotoxicity in normal human lung fibroblasts, making it a valuable tool for studies related to fibrosis and inflammation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
