Product Data Sheet
Lys-psi(CH2NH)-Trp(Nps)-OMe
Catalog No. A69455
Lys-psi(CH2NH)-Trp(Nps)-OMe is a pseudodipeptide analog of lysine and tryptophan designed to inhibit aminopeptidase activity. This compound exhibits significant analgesic properties, demonstrated through dose-dependent and naloxone-reversible responses following intracerebroventricular administration in murine models. It not only prolongs analgesic effects compared to its parent compound but also offers protection against the degradation of methionine enkephalin in rat striatal slices. Lys-psi(CH2NH)-Trp(Nps)-OMe's enhanced resistance to proteolysis contributes to its sustained analgesic activity, making it a valuable tool for studying pain mechanisms and the role of aminopeptidases in neuromodulation.
Chemical Information
| Catalog Num | A69455 |
|---|---|
| M. Wt | 485.60 |
| Formula | C24H31N5O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 141365-20-0 |
| Synonyms | LTNAM |
| SMILES | O=C(OC)[C@@H](NC[C@@H](N)CCCCN)CC1=C(SC2=CC=CC=C2[N+]([O-])=O)NC3=C1C=CC=C3 |
Biological Activity
| Description | Lys-psi(CH2NH)-Trp(Nps)-OMe is a pseudodipeptide analog of lysine and tryptophan designed to inhibit aminopeptidase activity. This compound exhibits significant analgesic properties, demonstrated through dose-dependent and naloxone-reversible responses following intracerebroventricular administration in murine models. It not only prolongs analgesic effects compared to its parent compound but also offers protection against the degradation of methionine enkephalin in rat striatal slices. Lys-psi(CH2NH)-Trp(Nps)-OMe's enhanced resistance to proteolysis contributes to its sustained analgesic activity, making it a valuable tool for studying pain mechanisms and the role of aminopeptidases in neuromodulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
