Product Data Sheet
PMPMEase-IN-1
Catalog No. A69577
PMPMEase-IN-1 is a selective inhibitor of carboxylesterase (CES) that targets PMPMEase activity, thereby modulating protein methylation processes. This compound demonstrates potential anti-cancer activity by enhancing sensitivity to polyisoprenyl derivatives, with an effective concentration (EC50) observed in inducing degeneration of human neuroblastoma SH-SY5Y cells. By specifically inhibiting PMPMEase, PMPMEase-IN-1 may contribute to the regulation of polyisoprenyl protein metabolism, promoting normal cellular function. Its utility in research could pave the way for therapeutic advancements in treating cancer and degenerative diseases.
Chemical Information
| Catalog Num | A69577 |
|---|---|
| M. Wt | 280.42 |
| Formula | C12H21FO2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1190196-76-9 |
| Synonyms | |
| SMILES | O=S(CCSC/C=C(C)/CC/C=C(C)\C)(F)=O |
Biological Activity
| Description | PMPMEase-IN-1 is a selective inhibitor of carboxylesterase (CES) that targets PMPMEase activity, thereby modulating protein methylation processes. This compound demonstrates potential anti-cancer activity by enhancing sensitivity to polyisoprenyl derivatives, with an effective concentration (EC50) observed in inducing degeneration of human neuroblastoma SH-SY5Y cells. By specifically inhibiting PMPMEase, PMPMEase-IN-1 may contribute to the regulation of polyisoprenyl protein metabolism, promoting normal cellular function. Its utility in research could pave the way for therapeutic advancements in treating cancer and degenerative diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
