Product Data Sheet
KS15
Catalog No. A69666
KS15 is a selective inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer, essential for circadian rhythm regulation. By disrupting the feedback actions of CRYs on E-box-dependent transcription, KS15 demonstrates an EC50 of 4.9 μM and exhibits anti-proliferative activity. This reagent is valuable for research into circadian biology and the role of cryptochromes in transcriptional regulation.
Chemical Information
| Catalog Num | A69666 |
|---|---|
| M. Wt | 420.30 |
| Formula | C20H22BrNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1033781-20-2 |
| Synonyms | |
| SMILES | CCO[C@@H](C(O)=O)CC1=CC(/C(C)=N/OCC2=CC=C(C=C2)Br)=CC=C1 |
Biological Activity
| Description | KS15 is a selective inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer, essential for circadian rhythm regulation. By disrupting the feedback actions of CRYs on E-box-dependent transcription, KS15 demonstrates an EC50 of 4.9 μM and exhibits anti-proliferative activity. This reagent is valuable for research into circadian biology and the role of cryptochromes in transcriptional regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
