Product Data Sheet
Abiraterone-d4
Catalog No. A69712
Abiraterone-d4, a deuterium-labeled derivative of Abiraterone, functions as a potent and irreversible inhibitor of the enzyme CYP17A1. By specifically targeting the cytochrome P450 enzyme CYP17, it effectively inhibits both 17α-hydroxylase and 17,20-lyase activities, displaying IC50 values of 2.5 nM and 15 nM, respectively. This reagent is crucial for studies investigating androgen synthesis pathways and the development of therapies for hormone-sensitive cancers.
Chemical Information
| Catalog Num | A69712 |
|---|---|
| M. Wt | 353.53 |
| Formula | C24H27D4NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2122245-62-7 |
| Synonyms | CB-7598-d4 |
| SMILES | C[C@@]12C(C3=C([2H])N=C([2H])C([2H])=C3[2H])=CC[C@]1([C@@]4(CC=C5[C@@](C)([C@]4(CC2)[H])CC[C@@H](C5)O)[H])[H] |
Biological Activity
| Description | Abiraterone-d4, a deuterium-labeled derivative of Abiraterone, functions as a potent and irreversible inhibitor of the enzyme CYP17A1. By specifically targeting the cytochrome P450 enzyme CYP17, it effectively inhibits both 17α-hydroxylase and 17,20-lyase activities, displaying IC50 values of 2.5 nM and 15 nM, respectively. This reagent is crucial for studies investigating androgen synthesis pathways and the development of therapies for hormone-sensitive cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
