Product Data Sheet
Nampt-IN-5
Catalog No. A69773
Nampt-IN-5 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a crucial enzyme in the NAD+ biosynthesis pathway. It demonstrates significant biological activity with cellular IC50 values of 0.7 nM against A2780 cells and 3.9 nM against COR-L23 cells, indicating strong efficacy in targeting cancer metabolism. In addition, Nampt-IN-5 inhibits CYP3A4 activity, making it relevant for studies on drug metabolism and potential interactions. Research applications include cancer cell metabolism and the investigation of therapeutic strategies targeting NAD+ pathways.
Chemical Information
| Catalog Num | A69773 |
|---|---|
| M. Wt | 427.50 |
| Formula | C25H25N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2380013-17-0 |
| Synonyms | |
| SMILES | O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3 |
Biological Activity
| Description | Nampt-IN-5 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a crucial enzyme in the NAD+ biosynthesis pathway. It demonstrates significant biological activity with cellular IC50 values of 0.7 nM against A2780 cells and 3.9 nM against COR-L23 cells, indicating strong efficacy in targeting cancer metabolism. In addition, Nampt-IN-5 inhibits CYP3A4 activity, making it relevant for studies on drug metabolism and potential interactions. Research applications include cancer cell metabolism and the investigation of therapeutic strategies targeting NAD+ pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
