Product Data Sheet
2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate
Catalog No. A69784
2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is a deuterium-labeled derivative of Octinoxate, functioning primarily as a thyroid hormone receptor agonist. This compound has been shown to decrease levels of triiodothyronine (T3) and thyroxine (T4), along with transcription levels of genes associated with type II deiodinase (deio2) in Japanese Medaka, supporting its role in endocrine research. Additionally, it is utilized as a UV filter in aquatic environments and exhibits inhibitory effects on CYP1A1 and CYP1B1, influencing hyaluronan metabolism through the PI3K pathway in human keratinocytes. Its anti-estrogenic and anti-androgenic properties have been demonstrated in both in vitro and in vivo studies, making it valuable for hormonal modulation research.
Chemical Information
| Catalog Num | A69784 |
|---|---|
| M. Wt | 293.42 |
| Formula | C18H23D3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2734919-82-3 |
| Synonyms | |
| SMILES | CCCCC(COC(/C=C/C1=CC=C(C=C1)OC([2H])([2H])[2H])=O)CC |
Biological Activity
| Description | 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is a deuterium-labeled derivative of Octinoxate, functioning primarily as a thyroid hormone receptor agonist. This compound has been shown to decrease levels of triiodothyronine (T3) and thyroxine (T4), along with transcription levels of genes associated with type II deiodinase (deio2) in Japanese Medaka, supporting its role in endocrine research. Additionally, it is utilized as a UV filter in aquatic environments and exhibits inhibitory effects on CYP1A1 and CYP1B1, influencing hyaluronan metabolism through the PI3K pathway in human keratinocytes. Its anti-estrogenic and anti-androgenic properties have been demonstrated in both in vitro and in vivo studies, making it valuable for hormonal modulation research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
