Product Data Sheet
IDO1-IN-30
Catalog No. A69884
IDO1-IN-30 is a selective and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), demonstrating an IC50 of 4.8 nM in SKOV3 cells. This compound exhibits minimal cytotoxicity in HepG2 cells at concentrations up to 25 µM and does not significantly inhibit CYP450 enzymes, including 3A4, 2C9, and 2D6. IDO1-IN-30 is suitable for studies focused on cancer immunotherapy and the modulation of inflammatory responses.
Chemical Information
| Catalog Num | A69884 |
|---|---|
| M. Wt | 398.37 |
| Formula | C19H16F2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2581050-29-3 |
| Synonyms | |
| SMILES | FC1=C(OC)C=C(F)C(N2N=NC([C@H](O)C3=C(N=CC4=CN=CN34)C5CC5)=C2)=C1 |
Biological Activity
| Description | IDO1-IN-30 is a selective and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), demonstrating an IC50 of 4.8 nM in SKOV3 cells. This compound exhibits minimal cytotoxicity in HepG2 cells at concentrations up to 25 µM and does not significantly inhibit CYP450 enzymes, including 3A4, 2C9, and 2D6. IDO1-IN-30 is suitable for studies focused on cancer immunotherapy and the modulation of inflammatory responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
