Product Data Sheet
Imiprothrin
Catalog No. A69900
Imiprothrin is a potent inducer of CYP1A2, known for its significant effects on metallothionein 1a expression. This compound exhibits genotoxic and cytotoxic properties, evident through the initiation of detoxification responses in rat hepatocytes and the induction of chromosomal aberrations and micronucleus formation in bone marrow cells. Additionally, Imiprothrin prompts oxidative stress, resulting in lipid peroxidation and reactive oxygen species production, which can adversely affect liver and kidney functions. Though it inhibits weight gain and can lead to high mortality in female mice at elevated doses, it has not shown carcinogenicity in rat studies, with sensitive toxicity biomarkers including aspartate aminotransferase and total protein.
Chemical Information
| Catalog Num | A69900 |
|---|---|
| M. Wt | 318.37 |
| Formula | C17H22N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 72963-72-5 |
| Synonyms | |
| SMILES | O=C(OCN1C(=O)N(CC#C)CC1=O)C2C(C=C(C)C)C2(C)C |
Biological Activity
| Description | Imiprothrin is a potent inducer of CYP1A2, known for its significant effects on metallothionein 1a expression. This compound exhibits genotoxic and cytotoxic properties, evident through the initiation of detoxification responses in rat hepatocytes and the induction of chromosomal aberrations and micronucleus formation in bone marrow cells. Additionally, Imiprothrin prompts oxidative stress, resulting in lipid peroxidation and reactive oxygen species production, which can adversely affect liver and kidney functions. Though it inhibits weight gain and can lead to high mortality in female mice at elevated doses, it has not shown carcinogenicity in rat studies, with sensitive toxicity biomarkers including aspartate aminotransferase and total protein. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
