Product Data Sheet
3-Hydroxyflunitrazepam
Catalog No. A69920
3-Hydroxyflunitrazepam is the principal metabolite of Flunitrazepam, formed through 3-hydroxylation by the enzyme CYP3A4. This metabolite constitutes over 80% of Flunitrazepam's metabolic pathway in liver microsomes, highlighting its relevance in pharmacokinetics. The formation of 3-Hydroxyflunitrazepam is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole and Ritonavir, suggesting crucial implications for drug-drug interactions in therapeutic applications and metabolic studies.
Chemical Information
| Catalog Num | A69920 |
|---|---|
| M. Wt | 329.28 |
| Formula | C16H12FN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 67739-71-3 |
| Synonyms | 3-OH FNTZ |
| SMILES | O=C1C(O)N=C(C2=CC=CC=C2F)C3=CC([N+]([O-])=O)=CC=C3N1C |
Biological Activity
| Description | 3-Hydroxyflunitrazepam is the principal metabolite of Flunitrazepam, formed through 3-hydroxylation by the enzyme CYP3A4. This metabolite constitutes over 80% of Flunitrazepam's metabolic pathway in liver microsomes, highlighting its relevance in pharmacokinetics. The formation of 3-Hydroxyflunitrazepam is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole and Ritonavir, suggesting crucial implications for drug-drug interactions in therapeutic applications and metabolic studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
