Product Data Sheet
7α-Hydroxy-DHEA
Catalog No. A69986
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma.
Chemical Information
| Catalog Num | A69986 |
|---|---|
| M. Wt | 304.42 |
| Formula | C19H28O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 53-00-9 |
| Synonyms | 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one |
| SMILES | C[C@@]12[C@]3([H])[C@]([C@@H](C=C1C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C |
Biological Activity
| Description | 7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
