Product Data Sheet
N-Desmethyl imatinib
Catalog No. A70095
N-Desmethyl imatinib is an active metabolite of Imatinib, primarily targeting the c-Abl kinase by binding to its catalytic domain, thus inhibiting substrate phosphorylation. This compound exhibits significant biological activity by inhibiting c-Abl-mediated α-synuclein activation and modulating downstream inflammatory signaling pathways, which leads to apoptosis in K562 human leukemia cells. Research applications include the investigation of pediatric gastrointestinal stromal tumors, chronic myeloid leukemia, and potential implications in neurodegenerative disorders such as Parkinson's disease. Elevated plasma levels of N-Desmethyl imatinib following certain viral infections can offer insights into its therapeutic roles.
Chemical Information
| Catalog Num | A70095 |
|---|---|
| M. Wt | 479.59 |
| Formula | C28H29N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 404844-02-6 |
| Synonyms | Norimatinib; Imatinib metabolite N-Desmethyl imatinib; CGP 74588 |
| SMILES | O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4 |
Biological Activity
| Description | N-Desmethyl imatinib is an active metabolite of Imatinib, primarily targeting the c-Abl kinase by binding to its catalytic domain, thus inhibiting substrate phosphorylation. This compound exhibits significant biological activity by inhibiting c-Abl-mediated α-synuclein activation and modulating downstream inflammatory signaling pathways, which leads to apoptosis in K562 human leukemia cells. Research applications include the investigation of pediatric gastrointestinal stromal tumors, chronic myeloid leukemia, and potential implications in neurodegenerative disorders such as Parkinson's disease. Elevated plasma levels of N-Desmethyl imatinib following certain viral infections can offer insights into its therapeutic roles. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
