Product Data Sheet
7-Hydroxymethotrexate
Catalog No. A70151
7-Hydroxymethotrexate is a key metabolite of Methotrexate, primarily produced through the hepatic metabolism of the drug. It is involved in the inhibition of dihydrofolate reductase, thereby blocking the conversion of folic acid to tetrahydrofolate and subsequently disrupting DNA synthesis. This compound is significant in pharmacokinetic studies and therapeutic monitoring of Methotrexate, aiding in understanding its efficacy and safety profiles in various treatment regimens.
Chemical Information
| Catalog Num | A70151 |
|---|---|
| M. Wt | 470.44 |
| Formula | C20H22N8O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 5939-37-7 |
| Synonyms | |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3NC2=O)C)C=C1)=O |
Biological Activity
| Description | 7-Hydroxymethotrexate is a key metabolite of Methotrexate, primarily produced through the hepatic metabolism of the drug. It is involved in the inhibition of dihydrofolate reductase, thereby blocking the conversion of folic acid to tetrahydrofolate and subsequently disrupting DNA synthesis. This compound is significant in pharmacokinetic studies and therapeutic monitoring of Methotrexate, aiding in understanding its efficacy and safety profiles in various treatment regimens. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
