Product Data Sheet
N-Desmethyl imatinib-d8
Catalog No. A70170
N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia.
Chemical Information
| Catalog Num | A70170 |
|---|---|
| M. Wt | 487.63 |
| Formula | C28H21D8N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1185103-28-9 |
| Synonyms | Norimatinib-d8; Imatinib metabolite N-Desmethyl imatinib-d8; CGP 74588-d8 |
| SMILES | O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5C([2H])([2H])C([2H])([2H])NC([2H])([2H])C5([2H])[2H])C=C4 |
Biological Activity
| Description | N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
