Product Data Sheet
Hydroxy desmethyl Bosentan
Catalog No. A70398
Hydroxy desmethyl Bosentan is a metabolite of Bosentan, primarily produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. As a dual antagonist of endothelin-1 (ET) at the ETA and ETB receptors, it exhibits inhibitory constants (Ki) of 4.7 nM and 95 nM, respectively, in human smooth muscle cells. This compound is relevant for studies related to pulmonary arterial hypertension and provides insight into drug metabolism and pharmacokinetics of Bosentan.
Chemical Information
| Catalog Num | A70398 |
|---|---|
| M. Wt | 553.59 |
| Formula | C26H27N5O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 253688-62-9 |
| Synonyms | Ro 64-1056 |
| SMILES | O=S(C1=CC=C(C(C)(C)CO)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4O)=O |
Biological Activity
| Description | Hydroxy desmethyl Bosentan is a metabolite of Bosentan, primarily produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. As a dual antagonist of endothelin-1 (ET) at the ETA and ETB receptors, it exhibits inhibitory constants (Ki) of 4.7 nM and 95 nM, respectively, in human smooth muscle cells. This compound is relevant for studies related to pulmonary arterial hypertension and provides insight into drug metabolism and pharmacokinetics of Bosentan. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
