Product Data Sheet
N-Desmethyl imatinib mesylate
Catalog No. A70480
N-Desmethyl imatinib mesylate is an active metabolite of imatinib, primarily functioning as a selective inhibitor of the c-Abl kinase. It effectively binds to the c-Abl catalytic domain, obstructing substrate phosphorylation and inhibiting the c-Abl-mediated activation of α-synuclein, as well as associated inflammatory signaling pathways. This compound promotes apoptosis in K562 human leukemia cells and demonstrates enhanced plasma concentrations in gastrointestinal stromal tumor contexts, especially following mild SARS-CoV-2 infection. N-Desmethyl imatinib mesylate is valuable for research into Parkinson's disease, gastrointestinal stromal tumors, and chronic myeloid leukemia.
Chemical Information
| Catalog Num | A70480 |
|---|---|
| M. Wt | 575.68 |
| Formula | C29H33N7O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 404844-03-7 |
| Synonyms | Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate; CGP 74588 mesylate |
| SMILES | CS(=O)(O)=O.O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4 |
Biological Activity
| Description | N-Desmethyl imatinib mesylate is an active metabolite of imatinib, primarily functioning as a selective inhibitor of the c-Abl kinase. It effectively binds to the c-Abl catalytic domain, obstructing substrate phosphorylation and inhibiting the c-Abl-mediated activation of α-synuclein, as well as associated inflammatory signaling pathways. This compound promotes apoptosis in K562 human leukemia cells and demonstrates enhanced plasma concentrations in gastrointestinal stromal tumor contexts, especially following mild SARS-CoV-2 infection. N-Desmethyl imatinib mesylate is valuable for research into Parkinson's disease, gastrointestinal stromal tumors, and chronic myeloid leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
