Product Data Sheet
Regorafénib N-oxyde (M2)-13C,d3
Catalog No. A70750
Regorafénib N-oxyde (M2)-13C,d3 is a stable isotope-labeled derivative of Regorafénib N-oxyde (M2), which is an active metabolite of the multi-targeted kinase inhibitor Regorafenib. This compound primarily exerts its biological activity by inhibiting vascular endothelial growth factor receptors (VEGFR1/2/3), platelet-derived growth factor receptor beta (PDGFRβ), and other key oncogenic drivers, thereby affecting cellular proliferation and survival pathways. Regorafénib's inhibition profile includes IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM for its various targets, making it a valuable tool in cancer research and therapeutic studies.
Chemical Information
| Catalog Num | A70750 |
|---|---|
| M. Wt | 502.83 |
| Formula | C2013CH12D3ClF4N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2140317-01-5 |
| Synonyms | |
| SMILES | O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=[N+]1[O-])N[13C]([2H])([2H])[2H] |
Biological Activity
| Description | Regorafénib N-oxyde (M2)-13C,d3 is a stable isotope-labeled derivative of Regorafénib N-oxyde (M2), which is an active metabolite of the multi-targeted kinase inhibitor Regorafenib. This compound primarily exerts its biological activity by inhibiting vascular endothelial growth factor receptors (VEGFR1/2/3), platelet-derived growth factor receptor beta (PDGFRβ), and other key oncogenic drivers, thereby affecting cellular proliferation and survival pathways. Regorafénib's inhibition profile includes IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM for its various targets, making it a valuable tool in cancer research and therapeutic studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
