Product Data Sheet
1-Aminocyclopropane-1-carboxylic acid
Catalog No. A71175
1-Aminocyclopropane-1-carboxylic acid (ACC) is an endogenous metabolite that primarily targets NMDA receptors. At low glutamate concentrations, ACC functions as a small molecule agonist, enhancing NMDA receptor activity with an EC50 of 0.7-0.9 μM, while at high glutamate concentrations, it acts as a competitive antagonist with an EC50 of 81.6 nM. This dual action contributes to its neuroprotective effects, preventing neuronal cell death in ischemic models and inducing blood pressure reduction in hypertensive rats. Additionally, ACC has been shown to enhance object recognition memory and cognitive flexibility without affecting impulsivity, making it a valuable compound for studies in neurotoxicity and cognitive function.
Chemical Information
| Catalog Num | A71175 |
|---|---|
| M. Wt | 101.10 |
| Formula | C4H7NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 22059-21-8 |
| Synonyms | |
| SMILES | O=C(O)C1(N)CC1 |
Biological Activity
| Description | 1-Aminocyclopropane-1-carboxylic acid (ACC) is an endogenous metabolite that primarily targets NMDA receptors. At low glutamate concentrations, ACC functions as a small molecule agonist, enhancing NMDA receptor activity with an EC50 of 0.7-0.9 μM, while at high glutamate concentrations, it acts as a competitive antagonist with an EC50 of 81.6 nM. This dual action contributes to its neuroprotective effects, preventing neuronal cell death in ischemic models and inducing blood pressure reduction in hypertensive rats. Additionally, ACC has been shown to enhance object recognition memory and cognitive flexibility without affecting impulsivity, making it a valuable compound for studies in neurotoxicity and cognitive function. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
