Product Data Sheet
CRCD2
Catalog No. A71724
CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia.
Chemical Information
| Catalog Num | A71724 |
|---|---|
| M. Wt | 340.40 |
| Formula | C17H16N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 941185-83-7 |
| Synonyms | |
| SMILES | O=C(C1=C(NC(C2=CC3=C(N=CN3)C=C2)=O)SC4=C1CCCC4)N |
Biological Activity
| Description | CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
